Description

L-Phenylalanine-[Ring-2,6-3H(N)] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Phenylalanine, specifically labeled at the 2 and 6 positions of the aromatic ring. This compound is critical for advanced metabolic and biochemical research, enabling precise tracking and quantification of phenylalanine pathways in complex biological systems. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers in tracer studies, drug metabolism investigations, and protein synthesis research.

Application

• Biochemical Tracer Studies: Used as a radiolabeled tracer to investigate phenylalanine metabolism, transport mechanisms, and amino acid utilization in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracking the metabolic fate of phenylalanine-derived drugs and studying enzyme kinetics, particularly for disorders like phenylketonuria (PKU).
• Protein Biosynthesis Research: Employed to study the incorporation of phenylalanine into peptides and proteins, providing insights into translation rates and protein turnover.
• Neurochemical Research: Applied in studies of neurotransmitter precursor pathways, as phenylalanine is a precursor to tyrosine, dopamine, norepinephrine, and epinephrine.
• Diagnostic Agent Development: Serves as a key component in the development of radiolabeled probes and assays for metabolic disorders.
• Agricultural and Plant Biochemistry: Used in research on amino acid synthesis and nitrogen metabolism in plants.

Basic Information

Product Name	L-Phenylalanine-[Ring-2,6-3H(N)]
CAS No.	89186-44-7
Molecular Formula	C9H113H2NO2 *
Molecular Weight	~167.2 g/mol (unlabeled base)**
Synonyms	(S)-2-Amino-3-(2,6-3H2phenyl)propanoic acid; L-Phe(2,6-3H2); Tritiated L-Phenylalanine; [2,6-3H]-L-Phenylalanine; Phenylalanine-2,6-t2; 3H-L-Phenylalanine; L-β-Phenyl-α-alanine-2,6-3H2
EINECS	Contact for details

* Formula indicates tritium (3H) labeling at the specified ring positions. ** Exact molecular weight varies with specific activity.

Quality Control

Every batch of L-Phenylalanine-[Ring-2,6-3H(N)] is manufactured and controlled under a strict quality management system. Product identity, radiochemical purity, and specific activity are verified using advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data for radiochemical purity, specific activity, chemical purity, and solvent composition. Our quality commitment ensures material suitable for sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep the product in the original container within a secondary containment, preferably under an inert atmosphere to minimize oxidation. Store in a dedicated, well-ventilated area for radioactive materials in accordance with local regulations.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR / HPLC)	Conforms to reference standard
Specific Activity	Customizable (Typical range: 10-80 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 95% to ≥ 98%
Chemical Purity (HPLC)	≥ 98%
Solvent (for solutions)	Ethanol/Water or as specified
Radioactive Concentration	As per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.