Description

D-Mannitol, [1-14C]- is a carbon-14 labeled isotopologue of the sugar alcohol D-mannitol, specifically radiolabeled at the C-1 position. This compound is an essential tool for conducting precise metabolic and pharmacokinetic studies, enabling researchers to trace the absorption, distribution, metabolism, and excretion (ADME) pathways of mannitol and related compounds. It is primarily utilized by research scientists and quality control specialists in the pharmaceutical, biotechnology, and agrochemical industries for advanced analytical applications.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the in vivo and in vitro metabolic fate of pharmaceutical compounds.
• Biochemical Pathway Analysis: Employed in research to elucidate specific enzymatic pathways and transport mechanisms involving polyols.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive analytical methods like LC-MS/MS.
• Environmental Fate Studies: Applied in agrochemical research to study the degradation and movement of chemical agents in environmental systems.
• Medical Research: Used in studies related to renal function, blood-brain barrier permeability, and as a diagnostic agent in labeled form.

Basic Information

Product Name	D-Mannitol, [1-14C]-
CAS No.	88404-24-4
Molecular Formula	C6H14O6 (with 14C at position 1)
Molecular Weight	~182.17 g/mol (exact mass depends on 14C enrichment)
Synonyms	1-14C-Mannitol; [1-14C]Mannitol; D-[1-14C]Mannitol; Mannitol-1-14C; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol-1-14C; Mannitol (C-14 labeled); Radiolabeled Mannitol; Carbon-14 Labeled Mannitol
EINECS	Contact for details

Quality Control

Every batch of D-Mannitol, [1-14C]- is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure product integrity, including confirmation of radiochemical purity (typically >97% by HPLC), specific activity, and chemical identity. Certificates of Analysis (COA) detailing all relevant parameters are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. The product should be handled in accordance with all applicable radiation safety regulations and guidelines for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97.0%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified on label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.