Description

Ganciclovir Mono-o-Acetate is a key pharmaceutical intermediate and a chemically modified derivative of the antiviral drug ganciclovir. This compound is critical for the synthesis of ganciclovir prodrugs, which are designed to enhance bioavailability and therapeutic efficacy. It is primarily utilized by manufacturers in the pharmaceutical and biotechnology sectors engaged in antiviral drug development and production, particularly for cytomegalovirus (CMV) and other herpesvirus infections.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of ganciclovir and its more bioavailable prodrug forms, such as valganciclovir.
• Antiviral Drug Development: Serves as a crucial building block in research and development of nucleoside analogue antiviral agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of finished dosage forms for antiviral medications.
• Biochemical Research: Employed in virology and molecular biology studies to investigate mechanisms of antiviral action and resistance.
• Reference Standard: Can be utilized as a high-purity standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Ganciclovir Mono-o-Acetate
CAS No.	88110-89-8
Molecular Formula	C11H17N5O5
Molecular Weight	299.28 g/mol
Synonyms	9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine Monoacetate; 2'-Nor-2'-deoxyguanosine Monoacetate Derivative; Ganciclovir Acetate; GCV Monoacetate; 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one Monoacetate; DHPG Mono-o-Acetate; BMY 29400 Monoacetate
EINECS	Contact for details

Quality Control

Our Ganciclovir Mono-o-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) documenting compliance with in-house specifications are available upon request. We support development projects with material suitable for research and GMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.