Description

Dl-Leucine-1,2-13C2 CAS NO 87994-88-5 is a stable isotope-labeled analog of the essential amino acid leucine, specifically enriched with carbon-13 at the 1 and 2 positions. This compound is a critical tool for advanced research in metabolism, protein synthesis, and nutritional studies, providing a non-radioactive tracer for precise analytical measurements. It is primarily utilized by research scientists and analytical laboratories in the fields of pharmaceutical development, clinical diagnostics, and metabolic research.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies to investigate amino acid and protein metabolism in vivo and in vitro.
• Biomedical Research: Essential for quantitative proteomics and biomarker discovery, enabling precise measurement of protein turnover rates and metabolic fluxes.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation of labeled amino acids into therapeutic proteins or to study drug-amino acid interactions.
• Nutritional Science: Applied in human and animal studies to assess protein utilization, requirements, and the impact of dietary interventions on muscle protein synthesis.
• Internal Standard for Analytics: Serves as a high-purity internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of leucine in complex biological samples.

Basic Information

Item	Detail
Product Name	Dl-Leucine-1,2-13C2
CAS No.	87994-88-5
Molecular Formula	C413C2H13NO2
Molecular Weight	135.15 g/mol (for 13C2 labeled form)
Synonyms	(±)-2-Amino-4-methylpentanoic-1,2-13C2 acid; DL-Leucine-1,2-13C2; 13C2-DL-Leucine; Leucine-1,2-13C2 (racemic); 4-Methyl-2-aminopentanoic-1,2-13C2 acid; (RS)-2-Amino-4-methylpentanoic-1,2-13C2 acid; 2-Amino-4-methylvaleric-1,2-13C2 acid; (±)-Leucine-1,2-13C2
EINECS	Contact for details

Quality Control

Our Dl-Leucine-1,2-13C2 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and spectroscopic confirmation. We support compliance with relevant research and quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (1,2 positions)
Chemical Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Racemic mixture (DL-form)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.