Description

5-(2,4-Difluorophenyl)-Picolinic Acid is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique difluorophenyl-picolinic acid structure makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand for Catalysis: Serves as a precursor for creating specialized ligands used in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig amination.
• Material Science Research: Employed in the development of organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology Probes: Utilized as a core structure for designing molecular probes and inhibitors to study enzyme function and biological pathways.

Basic Information

Product Name	5-(2,4-Difluorophenyl)-Picolinic Acid
CAS No.	87789-67-1
Molecular Formula	C₁₂H₇F₂NO₂
Molecular Weight	235.19 g/mol
Synonyms	5-(2,4-Difluorophenyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-(2,4-difluorophenyl)-; 5-(2,4-Difluorophenyl)picolinate; 2,4-Difluoro-5-(2-pyridyl)benzoic acid; Picolinic acid, 5-(2,4-difluorophenyl)-; 87789-67-1; 5-(2,4-Difluorophenyl)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(2,4-Difluorophenyl)-Picolinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.