Description

(S)-2-(tert-Butyldimethylsilyloxy)Propanal is a high-value chiral building block and protected aldehyde derivative essential for asymmetric synthesis. This compound matters for its role as a key intermediate in the production of complex pharmaceutical molecules and fine chemicals, enabling precise stereochemical control. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and cardiovascular drugs.
• Asymmetric Synthesis: Used in stereoselective reactions, including aldol condensations, nucleophilic additions, and reductive aminations, to construct complex molecular architectures.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products and bioactive compounds requiring specific (S)-configuration.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where stereochemistry impacts biological activity.
• Ligand and Catalyst Preparation: Used in the preparation of chiral ligands and organocatalysts for enantioselective catalysis.
• Fine Chemical Production: A versatile intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Item	Detail
Product Name	(S)-2-(tert-Butyldimethylsilyloxy)Propanal
CAS No.	87727-28-4
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	(S)-2-[(tert-Butyldimethylsilyl)oxy]propanal; (S)-2-(TBDMSO)Propanal; (S)-2-(tert-Butyldimethylsiloxy)propanal; (S)-2-(Tert-butyldimethylsilyloxy)propionaldehyde; (S)-TBDMS Protected Lactaldehyde; (S)-2-Hydroxypropanal TBDMS ether; (S)-O-TBDMS-Lactaldehyde; (S)-2-(tert-Butyldimethylsilyloxy)propionaldehyde
EINECS	Contact for details

Quality Control

Our (S)-2-(tert-Butyldimethylsilyloxy)Propanal is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We employ advanced analytical techniques, including chiral HPLC, NMR, and GC-MS, to verify identity, purity, and absence of critical impurities. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.