Description

Arabinofuranosyl-E-5-Iodovinyluracil is a synthetic nucleoside analogue, a modified uracil derivative designed for targeted biochemical research and pharmaceutical development. This compound is valued for its potential as a key intermediate or active pharmaceutical ingredient (API) in antiviral and anticancer research programs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate viral replication mechanisms, particularly for herpesviruses.
• Antiviral Drug Development: Acts as a potential precursor for prodrugs targeting viral thymidine kinase, a common strategy in anti-herpetic therapy.
• Radiopharmaceutical Precursor: The iodine moiety provides a handle for radiolabeling (e.g., with I-125 or I-131) for diagnostic imaging or targeted radiotherapy research.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based drugs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Arabinofuranosyl-E-5-Iodovinyluracil
CAS No.	87535-95-3
Molecular Formula	C11H11IN2O6
Molecular Weight	394.12 g/mol
Synonyms	1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-[(1E)-2-iodoethenyl]pyrimidine-2,4(1H,3H)-dione; (E)-5-(2-Iodovinyl)-1-β-D-arabinofuranosyluracil; (E)-IVDU; (E)-5-(2-Iodovinyl)-2'-deoxyuridine arabinoside; E-5-Iodovinyl-1-β-D-arabinofuranosyluracil; Ara-E-IVDU; BV-araU (E-isomer); Lodenosine analogue
EINECS	Contact for details

Quality Control

Our Arabinofuranosyl-E-5-Iodovinyluracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.