Description

Napamezole is a selective and potent α-2 adrenoceptor antagonist of significant interest in pharmacological research. Its primary value lies in its utility as a key reference standard and research chemical for studying neurotransmitter systems, cardiovascular function, and central nervous system disorders. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and contract research organizations (CROs) engaged in neuroscience and drug discovery programs.

Application

• Pharmacological Research: Used as a selective α-2 adrenergic receptor antagonist in in vitro and in vivo studies to elucidate receptor function and signaling pathways.
• Neuroscience Studies: A critical tool for investigating the role of noradrenergic systems in mood regulation, cognition, pain perception, and autonomic control.
• Drug Discovery & Development: Serves as a reference compound for screening, validating, and developing new therapeutic agents targeting adrenergic receptors.
• Biochemical Assays: Employed in receptor binding assays and functional tests to determine compound affinity and efficacy.
• Academic Research: Utilized in university and institutional labs for fundamental research into cardiovascular physiology and neuropharmacology.
• Analytical Standard: Provides a high-purity standard for method development and quality control in analytical chemistry, particularly in HPLC and LC-MS.

Basic Information

Product Name	Napamezole
CAS No.	87495-33-8
Molecular Formula	C15H18N2O
Molecular Weight	242.32 g/mol
Synonyms	2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline; 2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazole; 2-(1,2,3,4-Tetrahydro-1-naphthyl)imidazoline; (RS)-2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline; Napamezole Hydrochloride (salt form); α-2 adrenergic antagonist; Central α-2 antagonist
EINECS	Contact for details

Quality Control

Our Napamezole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 guidelines, and our analytical methods are validated to meet the rigorous standards expected by the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.