Description

n-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-n-Carboxyanhydride CAS NO 87269-99-6 is a specialized N-Carboxyanhydride (NCA) derivative, a critical building block in the synthesis of peptides and peptide-mimetic polymers. This high-purity intermediate enables precise control over polymer sequence and architecture, which is essential for advanced pharmaceutical and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for creating novel therapeutic agents and functional biomaterials.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Monomer for the ring-opening polymerization (ROP) to produce well-defined polypeptides and peptide-polymer hybrids with controlled molecular weights.
• Drug Delivery Systems: Synthesis of biodegradable and biocompatible polymeric carriers for targeted drug delivery and controlled release applications.
• Bioconjugation: Facilitating the site-specific attachment of peptides to proteins, antibodies, or other biomolecules for diagnostic and therapeutic purposes.
• Biomaterials Research: Development of scaffolds for tissue engineering, hydrogels, and other functional biomaterials that mimic natural extracellular matrices.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptides and peptidomimetics.

Basic Information

Product Name	n-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-n-Carboxyanhydride
CAS No.	87269-99-6
Molecular Formula	C18H23NO6
Molecular Weight	349.38 g/mol
Synonyms	L-Alanine, N-[1-[(ethoxycarbonyl)methyl]-3-phenylpropyl]-, N-carboxyanhydride; (S)-2-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoic acid N-carboxyanhydride; EPC-L-Ala-NCA; N-(1-(S)-Ethoxycarbonyl-3-phenylpropyl)-L-alanine NCA; Enalaprilat Precursor NCA; ACE Inhibitor Intermediate NCA; NCA-EPC-Ala
EINECS	Contact for details

Quality Control

Our n-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-n-Carboxyanhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, containers should be sealed under an inert atmosphere (e.g., nitrogen or argon) after opening and allowed to equilibrate to room temperature before use to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.