Description

Litoxetine CAS NO 86811-09-8 is a selective serotonin reuptake inhibitor (SSRI) compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential application as a key active pharmaceutical ingredient (API) or advanced intermediate for central nervous system (CNS) therapeutics. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel psychotropic medications.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the formulation of antidepressant and anxiolytic medications.
• Neuropharmacology Research: Critical reference standard and investigational compound for studying serotonin reuptake mechanisms and CNS drug discovery.
• Preclinical & Clinical Development: Serves as a key intermediate or final API in the development pipeline for new SSRIs and related CNS-targeting drugs.
• Contract Manufacturing: Supplied to CDMOs for the production of generic or proprietary formulations containing litoxetine.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and impurity profiling via HPLC, LC-MS, and other techniques.
• Academic & Institutional Research: Utilized in university and institutional labs for pharmacological studies and educational purposes.

Basic Information

Product Name	Litoxetine
CAS No.	86811-09-8
Molecular Formula	C17H18FNO
Molecular Weight	271.33 g/mol
Synonyms	Litoxetine; LY-248686; (3S)-3-[(Methylamino)methyl]-1,2,3,4-tetrahydro-9-(trifluoromethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one; 5H-[1]Benzopyrano[3,4-c]pyridin-5-one, 1,2,3,4-tetrahydro-9-(trifluoromethyl)-3-[(methylamino)methyl]-, (3S)-; (S)-Litoxetine; (+)-Litoxetine
EINECS	Contact for details

Quality Control

Our Litoxetine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for pharmaceutical R&D and production. We provide comprehensive analytical data supporting identity, purity, and impurity profiles, aligned with ICH guidelines. A Certificate of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and chiral purity is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require desiccant to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.