Description

n-(Deoxyguanosin-8-Yl)-4-Aminobiphenyl CAS NO 86408-34-6 is a specific DNA adduct formed by the covalent binding of the carcinogenic metabolite of 4-aminobiphenyl to the C8 position of deoxyguanosine. This compound is of critical importance as a biomarker for exposure to aromatic amines and for studying the mechanisms of chemical carcinogenesis. It is primarily required by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in toxicology, molecular epidemiology, and cancer research.

Application

• Biomarker Standard for Exposure Assessment: Used as a quantitative standard in analytical methods (e.g., HPLC-MS/MS, 32P-postlabeling) to measure human exposure to 4-aminobiphenyl, a known human bladder carcinogen found in tobacco smoke and industrial settings.
• Mechanistic Toxicology Research: Essential for in vitro and in vivo studies investigating the formation, persistence, and repair of specific DNA adducts, helping to elucidate the carcinogenic pathways of aromatic amines.
• Method Development and Validation: Serves as a critical reference material for developing and validating highly sensitive assays for DNA damage detection in biological samples.
• Cancer Risk Evaluation Studies: Employed in molecular epidemiology to correlate adduct levels with cancer risk, providing insights into individual susceptibility and the effectiveness of chemopreventive agents.
• Quality Control in Diagnostic Testing: Used as a positive control in laboratories offering biomonitoring services for occupational or environmental health assessments.
• Educational and Reference Material: Supplied to academic institutions for advanced teaching and research in chemical carcinogenesis and DNA damage.

Basic Information

Product Name	n-(Deoxyguanosin-8-Yl)-4-Aminobiphenyl
CAS No.	86408-34-6
Molecular Formula	C26H25N7O4
Molecular Weight	499.52 g/mol
Synonyms	N-(Deoxyguanosin-8-yl)-4-aminobiphenyl; 8-(4-Aminobiphenyl-1-yl)-2'-deoxyguanosine; dG-C8-ABP; ABP-DNA Adduct; 4-Aminobiphenyl-deoxyguanosine Adduct; N-(2'-Deoxyguanosin-8-yl)-4-aminobiphenyl; 8-(4-Aminobiphenyl)-2'-deoxyguanosine; DNA-4-Aminobiphenyl Adduct
EINECS	Contact for details

Quality Control

Our n-(Deoxyguanosin-8-Yl)-4-Aminobiphenyl is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, which is paramount for reliable scientific data. Each batch is characterized using advanced analytical techniques, including NMR and mass spectrometry, for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.