Description

n-(Deoxyguanosin-8-Yl)-1-Aminopyrene CAS NO 85989-43-1 is a well-characterized DNA adduct formed by the covalent binding of 1-aminopyrene to the C8 position of deoxyguanosine. This compound matters as a critical reference standard and biomarker in toxicology and environmental health research, enabling the study of polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage mechanisms. It is primarily needed by analytical laboratories, research institutions, and pharmaceutical companies engaged in carcinogenesis studies, biomonitoring, and the development of diagnostic assays for genetic toxicology.

Application

• Biomarker Standard for Exposure Assessment: Used as a quantitative standard in mass spectrometry (LC-MS/MS, GC-MS) to measure 1-aminopyrene-DNA adducts in biological samples, assessing human exposure to PAHs.
• Mechanistic Toxicology Research: Serves as a key tool for investigating the metabolic activation pathways of 1-aminopyrene and the resulting DNA adduct formation, repair, and mutagenic potential.
• Calibration in Analytical Chemistry: Essential for calibrating equipment and validating methods in laboratories specializing in DNA adductomics and chemical carcinogenesis.
• Reference Material in Pharmaceutical Safety: Employed in the pharmaceutical industry for genotoxicity testing of new chemical entities, helping to evaluate drug safety profiles.
• Environmental Health Studies: Facilitates research into the health impacts of air pollution, occupational exposure (e.g., in coke oven or diesel exhaust workers), and other environmental PAH sources.
• Educational and Method Development: Used in academic settings for teaching advanced analytical techniques and in developing new, sensitive detection methods for DNA damage.

Basic Information

Product Name	n-(Deoxyguanosin-8-Yl)-1-Aminopyrene
CAS No.	85989-43-1
Molecular Formula	C30H26N6O4
Molecular Weight	534.57 g/mol
Synonyms	1-Aminopyrene-deoxyguanosine adduct; N-(Deoxyguanosin-8-yl)-1-aminopyrene; 8-(1-Aminopyrenyl)deoxyguanosine; dG-C8-AP; APDE; Deoxyguanosine-1-aminopyrene adduct; DNA-1-aminopyrene adduct; 1-AP-DNA adduct
EINECS	Contact for details

Quality Control

Every batch of n-(Deoxyguanosin-8-Yl)-1-Aminopyrene is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Comprehensive Certificates of Analysis (COA) are provided, detailing results from HPLC purity analysis, spectroscopic identification (UV, NMR, MS), and moisture content. We support research requiring traceable and reliable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is light-sensitive and hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere (argon or nitrogen) to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (UV)	Spectrum matches reference
Purity (HPLC)	≥ 95% (Area % at 254 nm)
Water Content (KF)	≤ 3.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.