Description

(S)-(-)-1,2,3,4-Tetrahedro-Naphthoic Acid CAS NO 85777-52-2 is a high-purity, chiral carboxylic acid derivative of tetrahydronaphthalene, serving as a critical chiral building block and resolving agent in advanced organic synthesis. Its defined stereochemistry is essential for creating enantiomerically pure compounds, directly impacting the efficacy and safety profile of final products. This compound is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material or intermediate for the production of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutics.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of chiral ligands for metal-catalyzed asymmetric reactions, such as hydrogenation or cross-coupling.
• Chiral Resolving Agent: Employed for the separation of racemic mixtures of amines or other basic compounds via diastereomeric salt formation.
• Advanced Material Research: Investigated for the development of chiral liquid crystals or organic semiconductors where molecular handedness influences material properties.
• Academic & Process R&D: Serves as a valuable tool in academic research and process development for studying stereoselective reactions and optimizing synthetic routes.

Basic Information

Product Name	(S)-(-)-1,2,3,4-Tetrahedro-Naphthoic Acid
CAS No.	85777-52-2
Molecular Formula	C11H12O2
Molecular Weight	176.21 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-2-naphthoic Acid; (S)-(-)-1,2,3,4-Tetrahydro-2-naphthalenecarboxylic Acid; (S)-Tetrahydronaphthalene-2-carboxylic Acid; (2S)-1,2,3,4-Tetrahydronaphthalene-2-carboxylic Acid; (S)-THNA; L-THNA; (S)-Tetrahydronaphthoic Acid
EINECS	Contact for details

Quality Control

Our (S)-(-)-1,2,3,4-Tetrahedro-Naphthoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets exacting research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, assay, and impurities is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.