Description

6-Ethylidene-7-Oxo-3-Sulfo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate with a complex bicyclic β-lactam structure. Its primary value lies in its role as a critical building block for the synthesis of novel carbapenem antibiotics, which are essential in combating multi-drug resistant bacterial infections. This high-purity intermediate is vital for research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Carbapenem Antibiotic Synthesis: A crucial precursor in the multi-step synthesis of broad-spectrum carbapenem antibiotics like Meropenem and Biapenem.
• Pharmaceutical R&D: Serves as a key scaffold for medicinal chemists developing new antibacterial compounds with improved efficacy and resistance profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of final antibiotic drug substances under current Good Manufacturing Practices (cGMP).
• Chemical Process Development: Employed in optimizing and scaling up synthetic routes for cost-effective and sustainable antibiotic production.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing of finished antibiotic products.

Basic Information

Product Name	6-Ethylidene-7-Oxo-3-Sulfo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
CAS No.	85618-29-7
Molecular Formula	C9H9NO6S
Molecular Weight	259.24 g/mol
Synonyms	(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 3-Sulfonic Acid; 6-Ethylidene-7-oxo-3-sulfo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; Meropenem Intermediate; Biapenem Intermediate; 3-Sulfonatoazetidinone Derivative; Carbapenem Synthon; 85618-29-7; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-ethylidene-7-oxo-3-sulfo-
EINECS	Contact for details

Quality Control

Our 6-Ethylidene-7-Oxo-3-Sulfo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring material that aligns with ICH guidelines and cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.