Description

8(R,S)-Hydroxy-11(S),12(S)-Epoxyeicosa-5Z,9E,14Z-Trienoic Acid is a specialized eicosanoid derivative, a key intermediate in the study of lipid signaling pathways and inflammation biochemistry. This compound matters for its role as a precursor to bioactive lipid mediators, enabling critical research into cellular regulation and metabolic processes. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and contract research organizations (CROs) focused on developing novel therapeutics for inflammatory and cardiovascular diseases.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in analytical chemistry for the quantification and identification of related eicosanoids in biological samples.
• Lipid Mediator Synthesis: Serves as a crucial synthetic intermediate for the preparation of more complex epoxy- and hydroxy-eicosanoids in medicinal chemistry programs.
• Enzymology Studies: Employed as a substrate to investigate the activity and inhibition of key enzymes like cytochrome P450 (CYP) epoxygenases and soluble epoxide hydrolase (sEH).
• Cell Signaling Pathway Analysis: Utilized in cell-based assays to study the downstream effects of epoxy fatty acids on inflammation, pain, and vascular function.
• Drug Discovery & Development: Acts as a key building block or pharmacological tool compound in early-stage discovery for targets related to metabolic and inflammatory disorders.

Basic Information

Product Name	8(R,S)-Hydroxy-11(S),12(S)-Epoxyeicosa-5Z,9E,14Z-Trienoic Acid
CAS No.	85589-24-8
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	8-Hydroxy-11,12-epoxyeicosatrienoic acid; 8-HETE-Epoxide; 8-Hydroxy-11,12-EET; 8(R,S)-H-11(S),12(S)-EET; 8-HETE-11,12-epoxide; 8-Hydroxy-11,12-epoxy-5Z,9E,14Z-eicosatrienoic acid; (±)8-HETE-11,12-epoxide; 8-Hydroxy-11,12-epoxy-5,9,14-eicosatrienoic acid
EINECS	Contact for details

Quality Control

Our 8(R,S)-Hydroxy-11(S),12(S)-Epoxyeicosa-5Z,9E,14Z-Trienoic Acid is produced under strict quality management protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stability. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.