Description

(+)-1,3,4,14B-Tetrahydro-2,7-Dimethyl-2H-Dibenzo[B,F]Pyrazino[1,2-D]Oxazepine Maleate is a high-purity, complex heterocyclic compound supplied as the maleate salt. This product is critical for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for its role as a key chiral intermediate or active pharmaceutical ingredient (API) precursor.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of proprietary drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of new chemical entities (NCEs) where its specific tricyclic oxazepine core is integral to biological activity.
• Preclinical & Clinical Research: Supplied to research institutions and CROs (Contract Research Organizations) for pharmacological studies, toxicity testing, and formulation development.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory filings.
• Asymmetric Synthesis: Its chiral nature makes it valuable for studies in stereoselective synthesis and for creating libraries of enantiomerically pure compounds.

Basic Information

Product Name	(+)-1,3,4,14B-Tetrahydro-2,7-Dimethyl-2H-Dibenzo[B,F]Pyrazino[1,2-D]Oxazepine Maleate
CAS No.	85391-77-1
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	(+)-2,7-Dimethyl-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrazino[1,2-d][1,4]oxazepine maleate; (3R,14bR)-2,7-Dimethyl-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrazino[1,2-d][1,4]oxazepine (Z)-but-2-enedioate; Dexmethylphenidate Impurity; Dexmethylphenidate Related Compound; Focalin Impurity; (R,R)-Dexmethylphenidate Maleate; (R,R)-Methylphenidate Maleate; D-threo-Methylphenidate Maleate
EINECS	Contact for details

Quality Control

Our (+)-1,3,4,14B-Tetrahydro-2,7-Dimethyl-2H-Dibenzo[B,F]Pyrazino[1,2-D]Oxazepine Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.