Description

2-Bromo-4-(Chlorocarbonyl)-Alpha,Alpha,α-Trifluoroanisole is a high-value, multi-functional aromatic building block characterized by its reactive acid chloride and bromo-trifluoromethoxy substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of fluorine and specific aromatic frameworks is essential. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials, improving thermal stability and optical properties.
• Polymer Modification: Employed to introduce reactive sites and fluorinated aromatic units into specialty polymers for enhanced performance characteristics.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Peptide Mimetics & Bioconjugation: The acid chloride functionality is reactive towards amines and alcohols, useful for creating peptide analogs and linker molecules in bioconjugation.

Basic Information

Product Name	2-Bromo-4-(Chlorocarbonyl)-Alpha,Alpha,α-Trifluoroanisole
CAS No.	85366-63-8
Molecular Formula	C9H3BrClF3O2
Molecular Weight	303.47 g/mol
Synonyms	2-Bromo-4-(chlorocarbonyl)-α,α,α-trifluoroanisole; 4-Bromo-2-(trifluoromethoxy)benzoyl chloride; 2-Bromo-α,α,α-trifluoro-4-(trifluoromethoxy)benzoyl chloride (incorrect but common misnomer); 2-Bromo-4-(carboxylic acid chloride)-α,α,α-trifluoroanisole; Benzoyl chloride, 2-bromo-α,α,α-trifluoro-4-(trifluoromethoxy)-; 85366-63-8; 2-Bromo-4-(chloroformyl)-α,α,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Chlorocarbonyl)-Alpha,Alpha,α-Trifluoroanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs in research and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the acid chloride group. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.