Description

7,8-Dihydroxy-7,8-Dihydrovitamin D3 is a key intermediate metabolite in the vitamin D activation pathway, specifically formed during the catabolism of 1,25-dihydroxyvitamin D3. This compound is of significant interest for research into vitamin D metabolism, receptor interactions, and related biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemical standards and reference materials.

Application

• Biochemical Research: Critical intermediate for studying the metabolic pathways and catabolism of active vitamin D (calcitriol).
• Pharmaceutical Development: Used as a reference standard and synthetic precursor in the development of vitamin D analogs and metabolic modulators.
• Metabolite Analysis: Serves as a certified reference material (CRM) for the accurate quantification of vitamin D metabolites in biological samples via LC-MS/MS or HPLC.
• Enzyme Studies: Employed as a substrate to investigate the activity and inhibition of enzymes like CYP24A1 involved in vitamin D degradation.
• Cell Signaling Research: A tool compound for exploring non-genomic signaling pathways and receptor-mediated actions of vitamin D metabolites.

Basic Information

Product Name	7,8-Dihydroxy-7,8-Dihydrovitamin D3
CAS No.	84927-66-2
Molecular Formula	C₂₇H₄₄O₄
Molecular Weight	432.64 g/mol
Synonyms	7,8-Dihydroxy-7,8-dihydrocholecalciferol; 7,8-Dihydroxy-7,8-dihydro-D3; 7,8-Dihydroxy-7,8-dihydrovitamin D₃; 7,8-Dihydroxy-7,8-dihydro-Vitamin D3; 7,8-DiOH-7,8-dihydrovitamin D3; 7,8-Dihydroxyprevitamin D3 metabolite; 1α,25-Dihydroxyvitamin D3-7,8-diol precursor; Vitamin D3 catabolite intermediate
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxy-7,8-Dihydrovitamin D3 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.