Description

Pge2, [5,6,8,11,12,14,15-3H] is a high-specific-activity tritium-labeled analog of Prostaglandin E2, a critical eicosanoid signaling molecule. This radiolabeled compound is essential for advanced biochemical research, enabling precise tracking and quantification in metabolic and receptor binding studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on inflammation, pain, reproductive biology, and oncology pathways.

Application

• Receptor Binding Assays (RBA): Used to characterize and quantify prostaglandin EP receptor subtypes with high sensitivity.
• Metabolic Pathway Tracing: Tracks the biosynthesis, distribution, and catabolism of PGE2 in in vitro and ex vivo systems.
• Drug Discovery & Development: Serves as a key tool for screening and evaluating novel COX-2 inhibitors and prostaglandin receptor antagonists.
• Autoradiography Studies: Enables spatial visualization of PGE2 binding sites in tissue sections for pathological research.
• Enzyme Activity Assays: Measures the activity of enzymes like prostaglandin-E synthase in biochemical studies.
• Competitive Displacement Experiments: Determines binding affinities (IC50/Ki values) of unlabeled test compounds.

Basic Information

Product Name	Pge2, [5,6,8,11,12,14,15-3H]
CAS No.	84807-93-2
Molecular Formula	C20H28O5 (³H labeled)
Molecular Weight	~352.4 g/mol (unlabeled)
Synonyms	³H-Prostaglandin E2; Tritiated PGE2; [³H]PGE2; Dinoprostone-³H; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (tritium labeled); PGE2-³H; Prostaglandin E2 (tritiated); 9-Oxo-11α,15S-dihydroxy-prosta-5,13-dien-1-oic acid-³H
EINECS	Contact for details

Quality Control

Every batch of our tritium-labeled PGE2 is manufactured and analyzed under strict quality systems. Radiochemical purity and specific activity are confirmed via HPLC with radiometric detection to ensure >97% purity. A comprehensive Certificate of Analysis (COA), detailing specific activity (Ci/mmol), concentration, solvent system, and analytical chromatograms, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or lower in the original solvent as supplied. Avoid repeated freeze-thaw cycles. Due to its highly volatile nature (tritium), handle and store in accordance with local radiation safety regulations for low-level beta emitters.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Co-elutes with authentic PGE2 standard
Specific Activity	100-200 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Concentration	1.0 mCi/mL (approx.)
Solvent	Ethanol:Water (9:1) or custom
Radioisotope	³H (Tritium)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.