Description

12(S)-Hete-D8 is a deuterium-labeled analog of the bioactive lipid mediator 12(S)-HETE, a key metabolite in the arachidonic acid cascade. This stable isotope-labeled compound is essential for high-precision analytical research, providing an internal standard for accurate quantification in complex biological matrices. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors for advanced mass spectrometry and metabolic studies.

Application

• Internal standard for the quantitative analysis of 12(S)-HETE and related eicosanoids via LC-MS/MS and GC-MS.
• Critical reagent in drug metabolism and pharmacokinetic (DMPK) studies for tracing metabolic pathways.
• Use in biomedical research to investigate the role of 12(S)-HETE in inflammation, angiogenesis, and cancer biology.
• Application in the development and validation of clinical diagnostic assays for lipid mediators.
• Tool compound for isotope dilution analysis to ensure data accuracy and regulatory compliance in bioanalytical labs.
• Substrate for enzymatic studies involving lipoxygenases and other enzymes in the eicosanoid synthesis pathway.

Basic Information

Product Name	12(S)-Hete-D8
CAS No.	84807-90-9
Molecular Formula	C20H24D8O3
Molecular Weight	328.52 g/mol (approx.)
Synonyms	12(S)-Hydroxyeicosatetraenoic acid-d8; 12(S)-HETE-d8; (12S)-12-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid; 12S-HETE-d8; 12(S)-HETE (5,6,8,9,11,12,14,15-d8); Deuterated 12(S)-HETE; 12(S)-HETE Internal Standard
EINECS	Contact for details

Quality Control

Every batch of 12(S)-Hete-D8 is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to ensure compliance with research and analytical standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is moisture-sensitive; keep the original container sealed in a dry environment. For long-term storage, recommend storing at -80°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.