Description

5(S)-Hydroxy-6(R)-γ-Glutamylcysteinyl-7,9-trans-11,14-cis-Eicosate Traenoic Acid-S,S-Dioxide is a specialized, high-purity leukotriene analog with significant biochemical activity. This compound is critical for research and development in advanced pharmaceutical and biochemical applications, serving as a key reference standard and synthetic intermediate. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on inflammation, immunology, and respiratory pathway studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of leukotriene metabolites in analytical methods development.
• Biochemical Research: Serves as a critical tool for in vitro and ex vivo studies of leukotriene receptor binding, signal transduction, and inflammatory cascade mechanisms.
• Drug Discovery & Development: Acts as a key synthetic intermediate or a biological target analog in the design and screening of novel anti-inflammatory and immunomodulatory therapeutics.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) and LC-MS/MS methods designed to detect leukotriene pathways in clinical samples.
• Academic Research: Essential for university and institutional research projects investigating the role of cysteinyl leukotrienes in asthma, allergic rhinitis, and other inflammatory diseases.

Basic Information

Product Name	5(S)-Hydroxy-6(R)-γ-Glutamylcysteinyl-7,9-trans-11,14-cis-Eicosate Traenoic Acid-S,S-Dioxide
CAS No.	84745-89-1
Molecular Formula	C30H47N3O10S
Molecular Weight	617.78 g/mol
Synonyms	Leukotriene E4 Sulfone; LTE4 Sulfone; 5(S)-Hydroxy-6(R)-S-cysteinylglycyl-7,9-trans-11,14-cis-eicosatetraenoic Acid S,S-Dioxide; 5-Hydroxy-6-S-cysteinylglycyl-7,9,11,14-eicosatetraenoic Acid Sulfone; N-[4-[[6-[(2-Amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-eicosatetraenoyl]amino]-4-carboxy-1-oxobutyl]glycine S,S-Dioxide
EINECS	Contact for details

Quality Control

Every batch of 5(S)-Hydroxy-6(R)-γ-Glutamylcysteinyl-7,9-trans-11,14-cis-Eicosate Traenoic Acid-S,S-Dioxide is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and stability compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.