Description

D-[4-13C]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C-4 position (CAS NO 84270-10-0). This precise labeling makes it an indispensable tool for advanced metabolic research and diagnostic applications, enabling accurate tracing of glucose utilization and metabolic flux. It is primarily required by research institutions, pharmaceutical developers, and clinical diagnostic laboratories for studies in metabolism, drug development, and biomarker discovery.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates and network regulation in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in isotope dilution mass spectrometry to study the metabolic fate and bioavailability of new therapeutic compounds.
• Clinical Research & Diagnostics: Serves as a substrate in 13C-labeled breath tests (e.g., for liver function or gastric emptying) and in NMR/Mass Spec-based assays for metabolic disorders.
• Biochemical Research: Acts as a labeled precursor for investigating carbohydrate metabolism, glycolysis, and the pentose phosphate pathway.
• Nutritional Science: Utilized in human and animal studies to trace glucose absorption, distribution, and turnover.
• Isotope Labeling Standard: Functions as an internal standard for the precise quantification of D-glucose in complex biological matrices via mass spectrometry.

Basic Information

Product Name	D-[4-13C]Glucose
CAS No.	84270-10-0
Molecular Formula	C6H12O6 (with 13C at position 4)
Molecular Weight	~181.16 g/mol (exact mass depends on 13C enrichment)
Synonyms	4-13C-Glucose; D-Glucose-4-13C; (4-13C)Glucose; D-Glucose (4-13C); [4-13C]-D-Glucose; 4-Carbon-13 Labeled D-Glucose; D-Glucose-13C1 (C4); Stable Isotope Labeled D-Glucose
EINECS	Contact for details

Quality Control

Our D-[4-13C]Glucose is manufactured under strict quality systems to ensure high chemical and isotopic purity for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of biological contaminants. We adhere to relevant standards for research chemicals, and custom synthesis to meet specific purity or enrichment specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR/MS)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (at C-4)
Chemical Purity (HPLC)	≥ 98%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Biological Contamination	Sterile filtered, Endotoxin & Bioburden testing available

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.