Description

D-Fructose-4-13C is a stable isotope-labeled analog of fructose, a fundamental monosaccharide. This high-purity labeled compound is essential for advanced metabolic research and analytical method development, providing a critical tool for precise tracing and quantification. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in isotope dilution mass spectrometry (IDMS), metabolic flux analysis, and the development of certified reference materials.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of fructose and related metabolites in complex biological matrices like blood, urine, and tissue samples.
• Metabolic Pathway Tracing: Used in 13C metabolic flux analysis (MFA) to study carbohydrate metabolism, glycolysis, and the pentose phosphate pathway in cell cultures, microorganisms, and animal models.
• Clinical Diagnostics & Biomarker Research: Enables the development of highly specific and sensitive LC-MS/MS assays for diagnosing inborn errors of metabolism (e.g., hereditary fructose intolerance) and discovering metabolic biomarkers.
• Pharmaceutical R&D: Facilitates drug metabolism and pharmacokinetics (DMPK) studies to trace the metabolic fate of sugar-based pharmaceuticals and prodrugs.
• Nutritional Science Research: Investigates fructose absorption, utilization, and its role in metabolic disorders such as diabetes and non-alcoholic fatty liver disease (NAFLD).
• Certified Reference Material (CRM): Acts a primary material for calibrating analytical instruments and validating methods in food analysis and clinical laboratories.

Basic Information

Item	Detail
Product Name	D-Fructose-4-13C
CAS No.	84270-09-7
Molecular Formula	C6H12O6 (with 13C at position 4)
Molecular Weight	Contact for details
Synonyms	4-13C-Fructose; [4-13C]-D-Fructose; D-(-)-Fructose-4-13C; Levulose-4-13C; Fruit Sugar-4-13C; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-4-13C; Stable Isotope Labeled Fructose
EINECS	Contact for details

Quality Control

Every batch of D-Fructose-4-13C is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity by HPLC, and identity confirmation by NMR and MS. Our quality systems support compliance with the rigorous standards required for research and in-vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.