Description

10-(n-Methyl-D-Valine)Isocyclosporin A is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for advanced drug discovery and process development projects.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel immunosuppressant drugs and prodrugs.
• Biochemical Research: Used as a reference standard and active compound in studies investigating immunology, T-cell activation, and signal transduction pathways.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aimed at modifying the Cyclosporin A scaffold to enhance potency, selectivity, or pharmacokinetic properties.
• Process Development: Serves as a critical intermediate in the development and scale-up of synthetic routes for complex cyclic peptides.
• Analytical Standard: Employed in quality control laboratories for method development and validation, including HPLC and LC-MS analysis.

Basic Information

Product Name	10-(n-Methyl-D-Valine)Isocyclosporin A
CAS No.	83602-43-1
Molecular Formula	C63H113N11O12
Molecular Weight	1208.65 g/mol
Synonyms	10-(N-Methyl-D-valine)isocyclosporin A; [MeVal10]Isocyclosporin A; Isocyclosporin A, 10-(N-methyl-D-valine)-; Cyclosporin A Derivative; Cyclosporin A, 10-(N-methyl-D-valine)iso-; CsA Analog; Cyclosporin Isomer; Immunosuppressant Intermediate
EINECS	Contact for details

Quality Control

Our 10-(n-Methyl-D-Valine)Isocyclosporin A is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.