Description

Cyclosporin F CAS NO 83574-28-1 is a potent cyclic undecapeptide belonging to the cyclosporin family of immunosuppressive agents. This compound is of significant interest for pharmaceutical research and development, particularly in the study of immunosuppression mechanisms and structure-activity relationships. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced therapeutic discovery. The product is supplied with a focus on high purity and batch-to-batch consistency to support critical R&D and manufacturing processes.

Application

• Immunosuppressive Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies investigating novel immunosuppressive therapies.
• Pharmaceutical Development: Used in the formulation development and process optimization for new drug candidates targeting autoimmune diseases and organ transplant rejection.
• Biochemical Research: Employed as a tool compound to study cyclophilin binding, T-cell activation pathways, and intracellular signal transduction mechanisms.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical laboratories.
• Fine Chemical Synthesis: Used as a building block or intermediate in the synthetic chemistry of more complex peptide-based pharmaceuticals.

Basic Information

Product Name	Cyclosporin F
CAS No.	83574-28-1
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin F; [Thr2, Leu5, D-Hiv8, Leu10]-Cyclosporin A; Ciclosporin F; Cyclosporine F; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
EINECS	Contact for details

Quality Control

Our Cyclosporin F is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet stringent specifications for research and development use. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.