Description

D-Glucose-2-13C-2-C-D is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C-2 position and deuterium at the adjacent carbon. This compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and metabolic flux in biological systems. It is a critical reagent for scientists and manufacturers in pharmaceutical development, clinical diagnostics, and nutritional research, where understanding detailed biochemical pathways is paramount.

Application

• Metabolic Pathway Tracing: Used as a tracer in in vivo and in vitro studies to elucidate glycolysis, gluconeogenesis, and the pentose phosphate pathway.
• Quantitative NMR & Mass Spectrometry: Serves as an internal standard for the accurate quantification of glucose and its metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in pharmaceutical research to study the metabolic fate of new drug candidates and their interaction with glucose metabolism.
• Clinical Diagnostic Assays: Utilized in the development of advanced diagnostic tests for metabolic disorders such as diabetes and inborn errors of metabolism.
• Nutritional Science Research: Applied to investigate carbohydrate metabolism, energy expenditure, and substrate utilization in nutritional studies.
• Biotechnology & Fermentation Monitoring: Used in process optimization to monitor carbon source utilization in microbial and cell culture fermentations.

Basic Information

Product Name	D-Glucose-2-13C-2-C-D
CAS No.	83379-46-8
Molecular Formula	C513CH11DO6
Molecular Weight	183.15 g/mol (for major isotopologue)
Synonyms	D-[2-13C,2-2H]Glucose; (2-13C,2-2H)-D-Glucose; 2-13C,2-D-Glucose; D-Glucose-2-13C,2-d; Isotopically Labeled D-Glucose; [2-13C,2-2H]D-Glucopyranose; Stable Isotope-Labeled Glucose; 13C- and 2H-Double Labeled Glucose
EINECS	Contact for details

Quality Control

Every batch of D-Glucose-2-13C-2-C-D is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity through comprehensive analytical techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing the isotopic enrichment, chemical purity, and absence of critical impurities. Our quality commitment ensures reliability for your most sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (2H)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.5° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.