Description

Nefazodone CAS NO 83366-66-9 is a synthetic phenylpiperazine antidepressant compound. It is a high-purity active pharmaceutical ingredient (API) of significant importance in the research and development of central nervous system (CNS) therapeutics. This compound is primarily utilized by pharmaceutical manufacturers and research institutions engaged in neuropharmacology and drug discovery.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of antidepressant medications.
• Critical reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research exploring serotonin receptor antagonism and reuptake inhibition.
• Used in preclinical and clinical studies to investigate treatments for major depressive disorder and anxiety.
• Essential material for pharmacology and toxicology research within academic and institutional settings.

Basic Information

Product Name	Nefazodone
CAS No.	83366-66-9
Molecular Formula	C25H32ClN5O2
Molecular Weight	470.01 g/mol
Synonyms	Nefazodone Hydrochloride; MJ-13754-1; Serzone; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one; 1-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
EINECS	Contact for details

Quality Control

Our Nefazodone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.