Description

Serine, L-[3-3H] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-serine. This compound is critical for advanced biochemical research, enabling precise metabolic pathway tracing, protein synthesis studies, and receptor binding assays. It is an indispensable tool for researchers and scientists in the pharmaceutical, biotechnology, and life sciences sectors who require reliable radiolabeled tracers for autoradiography, pharmacokinetics, and molecular biology applications.

Application

• Biochemical and Metabolic Tracer Studies: Used to investigate serine metabolism, one-carbon unit transfer, and glycine synthesis pathways in cell cultures and animal models.
• Protein and Peptide Research: Employed in the radiolabeling of proteins and peptides to study synthesis rates, post-translational modifications, and degradation.
• Neurotransmitter and Receptor Binding Assays: Serves as a precursor in the synthesis of radiolabeled neuromodulators like D-serine for studying NMDA receptor function and neuropharmacology.
• Drug Discovery and Development: Facilitates ADME (Absorption, Distribution, Metabolism, Excretion) studies for candidate drugs that interact with serine-dependent pathways.
• Autoradiography and Imaging: Provides a high-resolution tracer for histological and whole-body imaging techniques to visualize tissue distribution and uptake.
• Enzyme Kinetics and Mechanism Studies: Used to elucidate the catalytic mechanisms of enzymes such as serine hydroxymethyltransferase and serine proteases.

Basic Information

Product Name	Serine, L-[3-3H]
CAS No.	83245-15-2
Molecular Formula	C3H43HNO3
Molecular Weight	~108.1 g/mol (for 3H form)
Synonyms	(2S)-2-Amino-3-hydroxy[3-3H]propanoic acid; L-[3-3H]Serine; Tritiated L-Serine; [3-3H]-L-Serine; L-Serine-3-t; (S)-2-Amino-3-hydroxy[3-3H]propionic acid; 3-Tritio-L-serine
EINECS	Contact for details

Quality Control

Every batch of Serine, L-[3-3H] is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity and specific activity. Our products undergo rigorous quality testing, including HPLC analysis for radiochemical purity and identity confirmation. Certificates of Analysis (COA) detailing specific activity, purity, solvent composition, and analytical methods are provided with each shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as supplied. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, keep in a dedicated freezer designated for radioactive materials. Always follow local radiation safety regulations for handling and storage.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water mixture (specified on COA)
Concentration	1 mCi/mL (Contact for other concentrations)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.