Description

(5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[[2-(Dimethylamino)-2-Iminoethyl]Thio]-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid CAS NO 82922-60-9 is a key advanced pharmaceutical intermediate, specifically a penem derivative, used in the synthesis of novel β-lactam antibiotics. This compound is critical for developing potent antibacterial agents with activity against a broad spectrum of resistant pathogens. It is primarily required by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) engaged in the development of next-generation anti-infective therapies.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in the multi-step synthesis of novel carbapenem and penem class antibiotics.
• Antibacterial Drug Research & Development: Used in medicinal chemistry programs to create new molecular entities targeting multidrug-resistant bacterial infections.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for β-lactam antibiotics.
• Reference Standard: Functions as a high-purity chemical reference standard for analytical method development, validation, and quality control in pharmaceutical production.
• Biochemical Research: Utilized in studies investigating the structure-activity relationships (SAR) and mechanism of action of β-lactam compounds.

Basic Information

Item	Details
Product Name	(5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[[2-(Dimethylamino)-2-Iminoethyl]Thio]-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
CAS No.	82922-60-9
Molecular Formula	C13H19N3O4S
Molecular Weight	313.37 g/mol
Synonyms	6-[(1R)-1-Hydroxyethyl]-3-[[2-(dimethylamino)-2-iminoethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[(2-(dimethylamino)-2-iminoethyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; Penem derivative intermediate; β-lactam intermediate; CAS 82922-60-9
EINECS	Contact for details

Quality Control

Our (5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[[2-(Dimethylamino)-2-Iminoethyl]Thio]-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.