Description

4-Fluoro-3-Methoxybenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 4-fluoro-3-methoxybenzoyl moiety, a key structural motif for modulating biological activity and material properties. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing central nervous system (CNS) agents, anti-inflammatory drugs, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and methoxy groups contribute to efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce functional side chains into polymers, enhancing properties like thermal stability, chemical resistance, and surface characteristics.
• Peptide & Protein Research: Acts as an acylating agent for modifying amino acids or protecting groups in peptide synthesis.
• Dye & Pigment Manufacturing: Intermediate for creating specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct complex biaryl systems.

Basic Information

Product Name	4-Fluoro-3-Methoxybenzoyl Chloride
CAS No.	82846-19-3
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	3-Methoxy-4-fluorobenzoyl chloride; 4-Fluoro-3-methoxybenzoic acid chloride; 4-Fluoro-m-anisoyl chloride; 3-Methoxy-4-fluorobenzoic acid chloride; 4-Fluoro-3-methoxybenzoyl chloride; 82846-19-3; 4-Fluoro-3-methoxy-benzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methoxybenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.