Description

Nefazodone Hydrochloride CAS NO 82752-99-6 is a high-purity pharmaceutical active ingredient, primarily known for its role as a serotonin antagonist and reuptake inhibitor (SARI). This compound is critical for the development and production of antidepressant medications, offering a distinct mechanism of action. It is essential for pharmaceutical manufacturers, research institutions, and API suppliers focused on central nervous system (CNS) therapeutics and generic drug development.

Application

• Primary Active Pharmaceutical Ingredient (API) in antidepressant formulations.
• Reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research for neuropsychiatric disorders.
• Raw material for the synthesis of novel chemical entities in medicinal chemistry.
• Critical component in bioequivalence and stability studies for generic drug applications.
• Used in preclinical and clinical research to study serotonin receptor pharmacology.

Basic Information

Product Name	Nefazodone Hydrochloride
CAS No.	82752-99-6
Molecular Formula	C25H32ClN5O2•HCl
Molecular Weight	506.92 g/mol
Synonyms	Nefazodone HCl; MJ-13754-1; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one Hydrochloride; Serzone (brand name); 1-(3-Chlorophenyl)-4-[3-(5-ethyl-4-(2-phenoxyethyl)-4H-1,2,4-triazol-3-yl)propyl]piperazine Hydrochloride
EINECS	Contact for details

Quality Control

Our Nefazodone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, confirming compliance with relevant pharmacopeial standards (such as USP/EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.