Description

3-(3-(Trifluoromethyl)Phenyl)-5-Isothiazolecarboxylic Acid is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. Its core value lies in the unique combination of the isothiazole ring and the trifluoromethylphenyl group, which imparts significant electronic and steric properties to target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms and heterocyclic core can contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialized ligands, monomers, or functional materials that require specific electronic characteristics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(3-(Trifluoromethyl)Phenyl)-5-Isothiazolecarboxylic Acid
CAS No.	82424-94-0
Molecular Formula	C11H6F3NO2S
Molecular Weight	273.23 g/mol
Synonyms	5-Isothiazolecarboxylic acid, 3-[3-(trifluoromethyl)phenyl]-; 3-(3-Trifluoromethylphenyl)-1,2-thiazole-5-carboxylic acid; 3-(α,α,α-Trifluoro-m-tolyl)isothiazole-5-carboxylic acid; 3-(3-(Trifluoromethyl)phenyl)isothiazole-5-carboxylic acid; 82424-94-0; 3-(3-Trifluoromethylphenyl)isothiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-(3-(Trifluoromethyl)Phenyl)-5-Isothiazolecarboxylic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic workflows. We employ advanced analytical techniques, including HPLC, NMR, and MS, for comprehensive identity and purity verification. A Certificate of Analysis (COA) detailing specific lot results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.