Description

Erythromycin, [n-Methyl-14C] is a carbon-14 radiolabeled derivative of the well-known macrolide antibiotic, erythromycin. This compound is specifically designed for use in advanced metabolic and pharmacokinetic studies, providing a critical tool for tracing and quantifying the fate of erythromycin and its metabolites within biological systems. It is an essential reagent for researchers and scientists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise analytical data for drug development and regulatory submissions.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of erythromycin in preclinical models.
• Metabolic Pathway Elucidation: Essential for identifying and characterizing the metabolic products and biotransformation pathways of erythromycin in vitro and in vivo.
• Bioanalytical Method Development: Serves as a critical internal standard or reference material in the development and validation of sensitive LC-MS/MS or radiochemical detection methods.
• Environmental Fate Studies: Applied in research to track the environmental persistence and breakdown of erythromycin-related compounds.
• Mechanistic Toxicology Research: Utilized to study the tissue-specific distribution and potential sites of toxicity for erythromycin and its analogs.

Basic Information

Product Name	Erythromycin, [n-Methyl-14C]
CAS No.	82343-12-2
Molecular Formula	C37H67NO13 * (14C-methyl labeled)
Molecular Weight	~ 735.9 g/mol (unlabeled base)
Synonyms	14C-Erythromycin; [Methyl-14C]-Erythromycin; Erythromycin-14C; Radiolabeled Erythromycin; Carbon-14 Labeled Erythromycin; Erythromycin A (14C-methyl); (3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione (14C-labeled)
EINECS	Contact for details

Quality Control

Every batch of Erythromycin, [n-Methyl-14C] is manufactured and handled under strict quality protocols to ensure radiochemical purity, specific activity, and chemical identity. Our products undergo rigorous quality testing, including HPLC with radiometric detection, to ensure compliance with the stringent requirements for radiolabeled compounds used in regulatory studies. A comprehensive Certificate of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material under an inert atmosphere. Follow all applicable laboratory safety and radiation safety guidelines for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, MS)	Conforms to reference standard
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Ethanol, Methanol, or as specified
Concentration (if supplied as solution)	0.1 mCi/mL or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.