Description

(3R)-3-[[(R)-2-Acetylamino-3-(4-Hydroxyphenyl)-1-Oxopropyl]Amino]-3-Methoxy-2-Oxo-1-Azetidinesulfonic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex azetidine sulfonic acid structure. This compound is critical for the synthesis of novel β-lactamase inhibitors and other specialized active pharmaceutical ingredients (APIs) where precise stereochemistry is paramount. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation antibacterial agents and enzyme inhibitors.

Application

• Key Intermediate for β-Lactamase Inhibitors: Serves as a crucial building block in the synthesis of advanced clavulanic acid analogs and other potent β-lactamase inhibitors used to combat antibiotic resistance.
• Pharmaceutical Research & Development: Employed in medicinal chemistry programs for the design and development of new antibacterial drugs targeting resistant bacterial strains.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to introduce the complex azetidine sulfonic acid moiety into target molecules for biological evaluation.
• Process Chemistry & Scale-Up: A vital material for process optimization and pilot-scale production runs in cGMP environments for new drug candidates.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(3R)-3-[[(R)-2-Acetylamino-3-(4-Hydroxyphenyl)-1-Oxopropyl]Amino]-3-Methoxy-2-Oxo-1-Azetidinesulfonic Acid
CAS No.	82227-66-5
Molecular Formula	C15H19N3O8S
Molecular Weight	401.39 g/mol
Synonyms	(3R,4R)-3-[[(R)-2-Acetylamino-3-(4-Hydroxyphenyl)-1-oxopropyl]amino]-3-methoxy-4-oxo-1-azetidinesulfonic acid; 3-Methoxy-3-[[(R)-2-acetylamino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-2-oxo-1-azetidinesulfonic acid; (3R)-3-[[(R)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methoxy-2-oxo-1-azetidinesulfonic Acid; Azetidinesulfonic acid derivative (CAS 82227-66-5); Advanced clavulanate intermediate; β-lactamase inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can support development activities requiring cGMP standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.