Description

(5R,6R)-3-[(Dihydroxymethyl)Sulfinyl]-7-Oxo-6-[(S)-1-(Sulfooxy)Ethyl]-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid CAS NO 82138-66-7 is a key advanced pharmaceutical intermediate with a complex β-lactam structure. This compound is of critical importance in the synthesis of next-generation carbapenem antibiotics, offering a pathway to molecules with enhanced potency and a broader spectrum of activity. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on developing novel anti-infective therapies.

Application

• Synthesis of Carbapenem Antibiotics: Serves as a crucial chiral building block in the production of advanced carbapenem-class antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs to create new analogs and explore structure-activity relationships for novel antibiotics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the final chemical synthesis steps for target antibiotic APIs under controlled GMP conditions.
• Process Chemistry Optimization: Employed in scaling up and optimizing synthetic routes for cost-effective and high-yield production of critical antibiotics.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(5R,6R)-3-[(Dihydroxymethyl)Sulfinyl]-7-Oxo-6-[(S)-1-(Sulfooxy)Ethyl]-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
CAS No.	82138-66-7
Molecular Formula	C12H15NO9S2
Molecular Weight	381.38 g/mol
Synonyms	(5R,6R)-3-[(Dihydroxymethyl)sulfinyl]-7-oxo-6-[(1S)-1-(sulfooxy)ethyl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; 6-[(1S)-1-(Sulfooxy)ethyl]-3-[(dihydroxymethyl)sulfinyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (5R,6R)-; Carbapenem intermediate; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivative; (5R,6R)-6-(1-Hydroxyethyl)-3-[[(hydroxymethyl)sulfinyl]methyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sulfate (ester); CAS 82138-66-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development and commercial projects requiring material that meets exacting pharmaceutical-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.