Description

Estra-1,3,5(10)-Trien-17-One, 3-((Bromoacetyl-2-14C)Oxy)- is a carbon-14 radiolabeled derivative of a key steroid intermediate, specifically designed for advanced research and development. This compound is critical for conducting precise metabolic, pharmacokinetic, and environmental fate studies where tracking molecular pathways is essential. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on endocrinology, steroid chemistry, and drug discovery. The product is supplied with a high specific activity to ensure reliable and sensitive detection in analytical applications.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of steroid-based pharmaceuticals.
• Biochemical Pathway Analysis: Enables the elucidation of steroid hormone biosynthesis and degradation pathways in biological systems.
• Environmental Fate Studies: Applied in research to track the environmental persistence and breakdown products of steroid compounds.
• Reference Standard for Analytical Method Development: Serves as a critical standard for calibrating and validating sensitive analytical techniques like Liquid Chromatography-Mass Spectrometry (LC-MS) and accelerator mass spectrometry (AMS).
• Synthesis of Radiolabeled Complex Molecules: Acts as a specialized building block for the synthesis of more complex carbon-14 labeled steroid analogs for research purposes.

Basic Information

Item	Details
Product Name	Estra-1,3,5(10)-Trien-17-One, 3-((Bromoacetyl-2-14C)Oxy)-
CAS No.	81949-03-3
Molecular Formula	C20H2314CO3Br
Molecular Weight	Contact for details
Synonyms	3-((Bromoacetyl-2-14C)oxy)estra-1,3,5(10)-trien-17-one; [2-14C]Bromoacetic Acid 3-Hydroxyestra-1,3,5(10)-trien-17-one Ester; 3-Hydroxyestra-1,3,5(10)-trien-17-one Bromoacetate-2-14C; Carbon-14 Labeled Estrone Bromoacetate; [2-14C]-3-Bromoacetoxyestra-1,3,5(10)-trien-17-one; Radiolabeled Estrone Derivative; 14C-Labeled Steroid Tracer
EINECS	Contact for details

Quality Control

Every batch of this radiolabeled compound is manufactured and analyzed under strict quality control protocols to ensure radiochemical purity, chemical purity, and specific activity meet exacting research standards. Our quality system emphasizes traceability and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, radio-HPLC, and other relevant spectroscopic analyses to confirm identity and purity.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solubility	Soluble in common organic solvents (e.g., DMSO, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.