Description

Xamoterol Hemifumarate is a selective β-1 adrenergic receptor partial agonist, primarily recognized for its pharmacological activity. This compound is of significant interest in the research and development of cardiovascular therapeutics due to its unique inotropic properties. It serves as a critical intermediate and reference standard for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on cardiology and receptor pharmacology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced cardiovascular drug candidates.
• Reference Standard: Used in analytical laboratories for quality control, method development, and calibration in HPLC, LC-MS, and other chromatographic systems.
• Biochemical Research: Employed in preclinical studies to investigate β-1 adrenergic receptor function, cardiac contractility, and heart failure mechanisms.
• Active Pharmaceutical Ingredient (API) Development: Utilized in the formulation development of potential therapeutic agents targeting cardiac conditions.
• Metabolite Studies: Acts as a precursor or standard for studying the metabolic pathways and pharmacokinetics of xamoterol-related compounds.

Basic Information

Item	Detail
Product Name	Xamoterol Hemifumarate
CAS No.	81801-12-9
Molecular Formula	C16H25N3O3 • 0.5C4H4O4
Molecular Weight	339.40 g/mol (free base: 291.39)
Synonyms	Xamoterol Fumarate (1:0.5); Corwin; ICI 118587; (RS)-N-[2-Hydroxy-3-(4-hydroxyphenoxy)propyl]morpholine-4-carboximidamide Hemifumarate; 4-Hydroxy-α-[[[2-(4-morpholinylcarbonyl)amino]ethyl]amino]methyl]-3-(phenoxy)-1-propanol Hemifumarate; (±)-Xamoterol Hemifumarate
EINECS	Contact for details

Quality Control

Our Xamoterol Hemifumarate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing specifications such as assay, related substances, and residual solvents. Our quality standards are designed to meet the requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.