Description

n-(3-Hydroxy-2-Pyridinylcarbonyl)-Cyclo[L-Thr*-D-Leu-[(4R)-4-Methyl-D-Pro-]Sar-n-Methyl-2-(1,2-Dimethylpropyl)-L-Gly-L-Ala-n-Methyl-L-Phenyl Gly-] is a complex, synthetic cyclic peptide derivative with a unique, constrained molecular architecture. This compound is of significant interest for its potential as a highly selective biological modulator in advanced pharmaceutical research and development. It is primarily sought after by pharmaceutical companies and research institutions engaged in the discovery of novel therapeutic agents, particularly in areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel peptide-based drug candidates.
• Protease Inhibitor Research: Investigated for its potential activity against specific proteolytic enzymes due to its constrained cyclic structure.
• GPCR (G-Protein Coupled Receptor) Targeting: Used in studies targeting GPCRs, a major class of drug targets, leveraging its complex peptidomimetic design.
• Chemical Biology Probes: Employed as a specialized tool compound to study protein-protein interactions and cellular signaling pathways.
• Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for medicinal chemistry optimization to enhance potency, selectivity, and metabolic stability.
• Preclinical Drug Development: Utilized in the early-stage development of oncological, metabolic, or neurological therapeutics.

Basic Information

Product Name	n-(3-Hydroxy-2-Pyridinylcarbonyl)-Cyclo[L-Thr*-D-Leu-[(4R)-4-Methyl-D-Pro-]Sar-n-Methyl-2-(1,2-Dimethylpropyl)-L-Gly-L-Ala-n-Methyl-L-Phenyl Gly-]
CAS No.	81720-11-8
Molecular Formula	C48H71N9O11
Molecular Weight	950.14 g/mol
Synonyms	Cyclo[L-Threonyl-D-leucyl-(4R)-4-methyl-D-prolyl-sarcosyl-N-methyl-2-(1,2-dimethylpropyl)glycyl-L-alanyl-N-methyl-L-phenylalanyl] 3-hydroxy-2-pyridinecarboxamide; L 156,602; L-156,602; L156602; Antibiotic L 156,602; [3-Hydroxypicolinoyl]cyclo[L-Thr-D-Leu-(4R)-Me-D-Pro-Sar-N-Me-(1,2-dimethylpropyl)Gly-L-Ala-N-Me-L-Phe]; Cyclic Peptide L156602; UNII-8F2XK2620K
EINECS	Contact for details

Quality Control

Our n-(3-Hydroxy-2-Pyridinylcarbonyl)-Cyclo[L-Thr*-D-Leu-[(4R)-4-Methyl-D-Pro-]Sar-n-Methyl-2-(1,2-Dimethylpropyl)-L-Gly-L-Ala-n-Methyl-L-Phenyl Gly-] is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC, MS, and NMR to ensure structural identity and high purity, meeting the stringent requirements for research-grade pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure (M+ = 950.14)
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.