Description

(+/-)-α-Methoxy-α-Trifluoromethylphenylacetic Acid CAS NO 81655-41-6 is a versatile chiral derivatizing agent and a key synthetic intermediate in organic chemistry. Its primary value lies in its ability to resolve enantiomers of chiral amines and alcohols, making it indispensable for analytical and preparative-scale applications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity chiral building blocks and analytical standards.

Application

• Chiral Resolution Agent: Widely used as a derivatizing agent for the NMR and HPLC analysis of enantiomeric purity of amines, amino acids, and alcohols.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in the preparation of enantiomerically pure compounds.
• Analytical Standard: Used as a high-purity reference standard in quality control laboratories for method development and validation.
• Agrochemical Research: Functions as an intermediate in the development of chiral pesticides and herbicides.
• Academic & R&D: A fundamental reagent in university and corporate research labs for exploring new asymmetric transformations and catalysis.

Basic Information

Product Name	(+/-)-α-Methoxy-α-Trifluoromethylphenylacetic Acid
CAS No.	81655-41-6
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	MTPA; α-Methoxy-α-(trifluoromethyl)phenylacetic acid; 2-Methoxy-2-(trifluoromethyl)phenylacetic acid; DL-MTPA; Mosher's Acid (racemic); (±)-MTPA; 2-Methoxy-2-(trifluoromethyl)benzenacetic acid; Racemic Mosher's acid
EINECS	Contact for details

Quality Control

Our production of (+/-)-α-Methoxy-α-Trifluoromethylphenylacetic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive analytical and synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for research and development as well as cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect purity and performance. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.