Description

(5R,6S)-6-(1-Hydroxyethyl)-7-Oxo-3-Pyridin-4-Ylsulfanyl-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid is a sophisticated, high-purity pharmaceutical intermediate with a complex bicyclic β-lactam structure. This compound is of critical importance in the synthesis of advanced carbapenem antibiotics, serving as a key chiral building block. It is primarily needed by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of novel anti-infective agents.

Application

• Key Intermediate for Carbapenem Antibiotics: Serves as a crucial precursor in the multi-step synthesis of potent, broad-spectrum carbapenem-class antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new β-lactam antimicrobial agents with improved efficacy.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex active pharmaceutical ingredients (APIs).
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for antibiotic production in pilot plants and commercial manufacturing.
• Academic Research: Applied in university and institutional labs for studying β-lactam synthesis methodologies, enzyme inhibition, and structure-activity relationships (SAR).

Basic Information

Product Name	(5R,6S)-6-(1-Hydroxyethyl)-7-Oxo-3-Pyridin-4-Ylsulfanyl-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
CAS No.	81520-91-4
Molecular Formula	C14H14N2O4S
Molecular Weight	306.34 g/mol
Synonyms	(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-(pyridin-4-ylsulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; 3-(4-Pyridylthio)carbapenem derivative; Carbapenem intermediate; 4-Pyridylthio substituted azabicycloheptene; (5R,6S)-6-(1-Hydroxyethyl)-3-[(4-pyridinyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; PNU-100480 related intermediate; Antibiotic synthesis intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (5R,6S isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.