Description

1H-Purine-2,6-Dione, 3,9-Dihydro-9-[(2-Hydroxyethoxy)Methyl]- CAS NO 81475-47-0 is a high-purity purine derivative, recognized as a key pharmaceutical intermediate. Its primary value lies in its role as a critical building block for the synthesis of nucleoside analogs, which are essential in modern antiviral and anticancer therapies. This compound is specifically required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of acyclovir (ACV) and its prodrug valacyclovir, widely used antiviral medications.
• Antiviral Drug Synthesis: Serves as a core scaffold for developing nucleoside analog drugs targeting herpes simplex virus (HSV), varicella-zoster virus (VZV), and other viral pathogens.
• Anticancer Research: Used in the research and development of purine-based chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Employed in enzymatic studies, nucleotide metabolism research, and as a reference standard in analytical laboratories.
• Fine Chemical Manufacturing: A key starting material for custom synthesis and the production of specialized, high-value chemical entities.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and GMP production of final drug substances.

Basic Information

Product Name	1H-Purine-2,6-Dione, 3,9-Dihydro-9-[(2-Hydroxyethoxy)Methyl]-
CAS No.	81475-47-0
Molecular Formula	C8H10N4O4
Molecular Weight	226.19 g/mol
Synonyms	9-[(2-Hydroxyethoxy)methyl]guanine; 2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one; HEG; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; Acyclovir Guanine; Acyclovir Intermediate; 9-(2-Hydroxyethoxymethyl)guanine; NSC 401005
EINECS	Contact for details

Quality Control

Our 1H-Purine-2,6-Dione, 3,9-Dihydro-9-[(2-Hydroxyethoxy)Methyl]- is manufactured under strict quality management systems. We offer grades suitable for research and GMP-driven pharmaceutical applications, with purity typically exceeding 98.0% (HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.