Description

L-Threonine, [U-14C] is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-threonine, identified by CAS NO 81325-81-7. This radiolabeled compound is a critical tool for metabolic pathway tracing, enabling precise quantification and visualization of threonine uptake and utilization in biological systems. It is primarily required by researchers and scientists in the pharmaceutical, agrochemical, and life science sectors for advanced studies in drug metabolism, protein synthesis, and nutritional biochemistry.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and biologics.
• Biochemical Pathway Analysis: Essential for tracing the metabolic fate of threonine in central carbon metabolism, one-carbon metabolism, and glycine/serine biosynthesis pathways.
• Protein Turnover and Synthesis Research: Employed in pulse-chase experiments to measure rates of protein synthesis and degradation in cell cultures, tissues, and whole organisms.
• Nutritional Science: Applied in studies to understand amino acid requirements, bioavailability, and inter-organ metabolism in animal models.
• Agricultural Chemistry: Used in research on amino acid uptake and metabolism in plants and soil microorganisms.
• Diagnostic Agent Development: Serves as a precursor for synthesizing radiolabeled probes for molecular imaging techniques like PET (Positron Emission Tomography), following appropriate isotopic conversion.

Basic Information

Product Name	L-Threonine, [U-14C]
CAS No.	81325-81-7
Molecular Formula	C144H9NO3 *
Molecular Weight	~121.1 g/mol (based on 14C)
Synonyms	(2S,3R)-2-Amino-3-hydroxy[U-14C]butanoic acid; L-2-Amino-3-hydroxy[U-14C]butyric acid; (2S,3R)-2-Amino-3-hydroxy[U-14C]butyric acid; Uniformly Labeled Carbon-14 L-Threonine; [U-14C]-L-Threonine; L-Threonine (U-14C); Threonine (U-14C)
EINECS	Contact for details

* Formula indicates uniform labeling with Carbon-14; exact atomic composition depends on specific activity.

Quality Control

Our L-Threonine, [U-14C] is manufactured and handled under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure high chemical, radiochemical, and enantiomeric purity. A detailed Certificate of Analysis (COA) is provided, specifying key parameters such as radionuclidic purity, radiochemical purity, specific activity, and chemical purity, typically determined by HPLC, TLC, and spectroscopic methods. Our quality commitment ensures reliable and reproducible results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture ingress. Store in accordance with all applicable local and national radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC, Co-chromatography)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC/TLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radionuclidic Purity	≥ 99%
Solvent (for solutions)	Specified on COA (e.g., Water, Ethanol)
Enantiomeric Purity	≥ 99% L-isomer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.