Description

L-Proline (1-13C) is a stable isotope-labeled analog of the amino acid L-proline, specifically enriched with carbon-13 at the 1-position. This compound is essential for advanced research and development, providing a critical tool for metabolic pathway tracing and structural elucidation in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications in NMR spectroscopy, mass spectrometry, and drug metabolism studies.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study the proline metabolic pathway and related cycles in cell cultures and organisms.
• NMR Spectroscopy: Serves as an internal standard or enriched probe for protein structure determination and dynamic studies.
• Mass Spectrometry (MS): Employed as a labeled internal standard for the accurate quantification of proline and related metabolites in complex samples.
• Drug Discovery & Development: Facilitates the study of drug metabolism and pharmacokinetics (DMPK) for compounds targeting proline-involved pathways.
• Biochemical Research: A key reagent in enzymatic studies and the investigation of collagen biosynthesis and other proline-dependent processes.
• Stable Isotope Labeling: Used in the production of other labeled compounds and peptides for research purposes.

Basic Information

Product Name	L-Proline (1-13C)
CAS No.	81202-06-4
Molecular Formula	C413CH9NO2
Molecular Weight	116.12 g/mol (for 13C1 labeled form)
Synonyms	(2S)-Pyrrolidine-2-carboxylic-1-13C acid; L-(-)-Proline-1-13C; Proline-1-13C; (S)-Proline-1-13C; 1-13C-L-Proline; L-Proline-1-13C; Proline (1-13C); 1-13C Labeled L-Proline
EINECS	Contact for details

Quality Control

Our L-Proline (1-13C) is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is tested to confirm identity, purity (by HPLC), isotopic enrichment (by NMR or MS), and the absence of specific impurities. Certificates of Analysis (COA) detailing these results are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	-84° to -86° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.