Description

L-Glutamic Acid (5-13C) is a stable isotope-labeled analog of the essential amino acid L-glutamic acid, where the carbon atom at the 5-position is enriched with the 13C isotope. This compound is a critical tool for advanced research and analytical applications, providing a reliable internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry, NMR spectroscopy, and metabolic flux analysis.

Application

• Mass Spectrometry (MS) Internal Standard: Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of L-glutamic acid in complex biological matrices.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a 13C-labeled tracer for studying metabolic pathways, protein structure, and dynamics in biochemical research.
• Metabolic Flux Analysis (MFA): Enables the detailed mapping and quantification of intracellular metabolic fluxes in microbial, plant, and mammalian cell cultures.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Clinical Diagnostics: Acts as a calibrant or control in diagnostic assays for inborn errors of metabolism related to glutamic acid.
• Nutritional Science Research: Used in studies investigating amino acid absorption, protein synthesis, and whole-body metabolism.

Basic Information

Product Name	L-Glutamic Acid (5-13C)
CAS No.	81202-00-8
Molecular Formula	C413CH9NO4
Molecular Weight	148.11 g/mol (for 13C1 labeled form)
Synonyms	(2S)-2-Aminopentanedioic-5-13C acid; L-Glutamic-5-13C acid; (S)-2-Aminopentanedioic-5-13C acid; 13C-L-Glutamic acid; Glutamic Acid-5-13C; L-Glu-5-13C; (S)-Glutamic-5-13C Acid; 13C Labeled L-Glutamic Acid
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid (5-13C) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity (by HPLC), chiral purity, and residual solvent content. We support compliance with various pharmacopeial standards where applicable. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]20/D: +31.5° to +32.5° (c=1 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.