Description

L-Tyrosine (Phenol-4-13C) is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, specifically labeled with carbon-13 at the 4-position of the phenolic ring. This precise labeling makes it an indispensable tool for advanced research requiring metabolic pathway tracing and quantitative analysis. It is primarily utilized by research scientists and analytical laboratories in the fields of pharmaceutical development, clinical diagnostics, and nutritional science.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of endogenous L-Tyrosine and related metabolites in complex biological matrices.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics of metabolic networks, particularly in research related to neurotransmitter synthesis, protein metabolism, and endocrine function.
• Pharmaceutical Research & Drug Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-containing drug candidates.
• Clinical Diagnostic Assays: Acts as a calibrator or control in high-precision diagnostic tests for inborn errors of metabolism, such as tyrosinemia.
• Nutritional Science Studies: Facilitates research into protein synthesis, amino acid bioavailability, and metabolic responses to dietary interventions using isotopic labeling techniques.
• Biochemical Research: Used in enzymatic studies and as a precursor in the synthesis of other labeled compounds, such as catecholamines (dopamine, norepinephrine).

Basic Information

Product Name	L-Tyrosine (Phenol-4-13C)
CAS No.	81201-90-3
Molecular Formula	C913CH11NO3
Molecular Weight	182.18 g/mol (for 13C1 labeled form)
Synonyms	(S)-2-Amino-3-(4-hydroxy-13C6H4)propanoic acid; L-Tyrosine-4-13C; L-Tyrosine (ring-4-13C); L-Tyrosine (phenol-13C6); 4-Hydroxy-13C6-L-phenylalanine; Isotopically Labeled L-Tyrosine; 13C-Labeled Tyrosine; Stable Isotope Amino Acid
EINECS	Contact for details

Quality Control

Our L-Tyrosine (Phenol-4-13C) is manufactured under strict quality systems to ensure the highest standards of isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters including isotopic enrichment (Atom % 13C), chemical purity, chiral purity, and specific tests for related substances. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Assay (HPLC)	≥ 98.0%
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.