Description

L-Valine-1-13C is a stable isotope-labeled analog of the essential amino acid L-Valine, where the carbon atom at the 1-position is enriched with the 13C isotope. This precise labeling makes it an indispensable tool for advanced metabolic research, drug development, and clinical diagnostics using techniques like Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in tracer studies, proteomics, and pharmacokinetic analysis.

Application

• Isotope Tracer Studies: Used as a metabolic tracer to investigate amino acid metabolism, protein synthesis rates, and metabolic pathways in biological systems.
• Mass Spectrometry (MS) Internal Standard: Serves as a critical internal standard for the accurate quantification of L-Valine in complex biological matrices (e.g., plasma, urine, tissue) via LC-MS/MS or GC-MS, ensuring high precision and reproducibility.
• NMR Spectroscopy: Employed in structural biology and metabolic flux analysis (MFA) to provide detailed insights into molecular structure and dynamic metabolic processes.
• Pharmaceutical R&D: Essential in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug compounds and their metabolites.
• Clinical Diagnostics: Used in the development of advanced diagnostic assays for metabolic disorders.
• Proteomics & Biomarker Discovery: Facilitates accurate protein quantification and the discovery of disease-specific biomarkers through stable isotope labeling techniques.

Basic Information

Product Name	L-Valine-1-13C
CAS No.	81201-85-6
Molecular Formula	C413CH11NO2
Molecular Weight	118.14 g/mol (for 13C1 labeled form)
Synonyms	(2S)-2-Amino-3-methylbutanoic-1-13C; L-2-Amino-3-methylbutyric-1-13C acid; Valine-1-13C; (S)-Valine-1-13C; 13C Labeled L-Valine; L-Valine (1-13C); Stable Isotope Labeled L-Valine; 13C1-L-Valine
EINECS	Contact for details

Quality Control

Our L-Valine-1-13C is manufactured under strict quality control protocols to ensure the highest standards of isotopic and chemical purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 13C), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry guidelines to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Optical Rotation	[α]20/D: +26° to +30° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.