Description

L-Serine-1-13C is a stable isotope-labeled analog of the essential amino acid L-serine, specifically enriched with carbon-13 at the 1-position. This precise labeling makes it an indispensable tool for advanced metabolic research, drug development, and clinical diagnostics, where accurate tracing of biochemical pathways is critical. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of diagnostic reagents and isotopically labeled standards.

Application

• Metabolic Pathway Tracing: Used as a 13C-labeled tracer in NMR and mass spectrometry studies to investigate serine metabolism, glycine synthesis, and one-carbon unit cycles.
• Pharmaceutical Research: Serves as a key building block in the development and testing of new drugs, enabling studies on drug metabolism, pharmacokinetics (DMPK), and biomarker discovery.
• Clinical Diagnostics: Employed as an internal standard in quantitative assays, such as Liquid Chromatography-Mass Spectrometry (LC-MS), for the accurate measurement of serine and related metabolites in biological fluids.
• Nutritional Science: Used in research to study amino acid requirements, protein synthesis, and metabolic disorders related to serine and glycine.
• Biochemical Reagent Production: A critical component in formulating high-precision kits and reagents for life science research and in vitro diagnostics (IVD).

Basic Information

Product Name	L-Serine-1-13C
CAS No.	81201-84-5
Molecular Formula	C313CH7NO3
Molecular Weight	106.09 g/mol (for 13C1 isotopologue)
Synonyms	(2S)-2-Amino-3-hydroxy(1-13C)propanoic acid; L-(1-13C)Serine; Serine-1-13C; (S)-Serine-1-13C; 13C Labeled L-Serine; L-Serine (1-13C); Isotope-labeled Serine; Stable Isotope-labeled Amino Acid
EINECS	Contact for details

Quality Control

Our L-Serine-1-13C is produced under strict quality management systems to ensure the highest standards of isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, chiral purity, and residual solvent content. We support research and production requiring compliance with cGMP, ISO, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.