Description

5,6-Epoxyretinoyl Glucuronide is a glucuronide conjugate metabolite of retinoic acid, a key compound in the retinoid signaling pathway. This high-purity reference standard is critical for research and development in metabolic studies and analytical method validation. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic researchers focused on vitamin A metabolism, dermatology, and oncology.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of retinoid metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Metabolic Pathway Research: Essential for studying the biotransformation, pharmacokinetics, and excretion pathways of vitamin A and synthetic retinoids.
• Dermatological Research: Investigated in studies related to skin cell differentiation, proliferation, and the mechanism of action of topical retinoid treatments.
• Oncological Research: Employed in research exploring the role of retinoid metabolites in cell differentiation, apoptosis, and cancer chemoprevention.
• Bioanalytical Method Development: Serves as a critical calibrant and system suitability standard for developing and validating robust analytical methods in compliance with ICH guidelines.
• Toxicology Studies: Used to assess metabolite profiles and exposure in preclinical and clinical safety evaluations of retinoid-based therapies.

Basic Information

Product Name	5,6-Epoxyretinoyl Glucuronide
CAS No.	81164-05-8
Molecular Formula	C₂₆H₃₄O₁₀
Molecular Weight	506.54 g/mol
Synonyms	5,6-Epoxyretinoic Acid Glucuronide; 5,6-Epoxyretinoyl-β-D-Glucuronide; Glucuronide, 5,6-Epoxyretinoyl; (all-E)-5,6-Epoxy-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid 1-(β-D-Glucopyranuronosyl) Ester; Retinoyl Glucuronide, 5,6-Epoxy-; Arotinoyl Glucuronide, 5,6-Epoxy-
EINECS	Contact for details

Quality Control

Every batch of 5,6-Epoxyretinoyl Glucuronide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced chromatographic and spectroscopic techniques to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, assay, and purity is provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.