Description

Hydroxyphenylethylamine Hydrochloride, [1-14C] is a carbon-14 labeled derivative of a key biogenic amine, essential for advanced metabolic and pharmacokinetic research. This radiolabeled compound provides a critical tool for tracing biochemical pathways with high specificity and sensitivity, enabling precise quantification in complex biological matrices. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery, neurochemical studies, and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to study the absorption, distribution, metabolism, and excretion of novel pharmaceutical compounds in preclinical models.
• Biochemical Pathway Elucidation: Enables the detailed mapping of metabolic pathways involving phenylethylamine derivatives in neurological and endocrine research.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive LC-MS/MS, HPLC, or radio-TLC methods.
• Receptor Binding and Enzyme Assays: Employed in in vitro studies to investigate ligand-receptor interactions or enzyme activity with high precision.
• Environmental Fate Studies: Applied in research to track the environmental degradation and transformation of similar amine-based compounds.

Basic Information

Product Name	Hydroxyphenylethylamine Hydrochloride, [1-14C]
CAS No.	80787-62-8
Molecular Formula	C8H12ClNO • 14C (specific activity varies)
Molecular Weight	~173.64 g/mol (unlabeled)
Synonyms	2-(4-Hydroxyphenyl)ethylamine-1-14C Hydrochloride; 4-Hydroxyphenethylamine-1-14C HCl; Tyramine-1-14C Hydrochloride; 4-(2-Aminoethyl)phenol-1-14C Hydrochloride; [1-14C]Tyramine Hydrochloride; p-Hydroxyphenethylamine-1-14C HCl; 4-HPEA-1-14C HCl
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and tested under stringent quality systems. Certificates of Analysis (COA) are provided, detailing critical parameters such as radiochemical purity, specific activity, and chemical purity. Our quality assurance protocols are designed to meet the exacting standards required for research use in regulated environments, ensuring traceability and reliability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC/TLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (customizable)
Solvent (for solution forms)	Ethanol/Water or custom

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.