Description

20-Carboxy-Leukotriene B4 is a key oxidized metabolite of the potent pro-inflammatory mediator Leukotriene B4 (LTB4). This compound is of significant value in biomedical research as a specific biomarker for monitoring LTB4 activity and oxidative stress pathways in biological systems. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and diagnostic sectors for advanced studies in inflammation, immunology, and respiratory diseases.

Application

• Biomarker Research: Used as a reference standard for the quantitative analysis of LTB4 metabolism in in vitro and in vivo studies.
• Drug Discovery & Development: Serves as a critical tool for screening and validating novel anti-inflammatory therapeutics targeting the leukotriene pathway.
• Diagnostic Assay Development: Employed in the calibration and development of immunoassays (ELISA) and LC-MS/MS methods for clinical and preclinical sample analysis.
• Mechanistic Studies: Essential for investigating the role of LTB4 and its metabolites in inflammatory diseases such as asthma, arthritis, and psoriasis.
• Academic Research: A vital reagent for university and institutional labs focusing on eicosanoid biochemistry, cell signaling, and oxidative biology.

Basic Information

Product Name	20-Carboxy-Leukotriene B4
CAS No.	80434-82-8
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	20-COOH-LTB4; 20-Carboxy-LTB4; 5(S),12(R)-Dihydroxy-6,8,10,14-eicosatetraenoic-1,20-dioic Acid; Leukotriene B4 20-Carboxylic Acid; 20-COOH-5(S),12(R)-DiHETE; ω-Carboxy-Leukotriene B4; 20-Carboxy-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Every batch of 20-Carboxy-Leukotriene B4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stability. Our standard quality commitment includes comprehensive characterization by HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent in-house specifications suitable for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.